Skip to main content

therapeutic conventional surgery (NCT05388773)

Transoral Surgical Resection Followed by De-escalated Adjuvant IMRT in Resectable p16+ Locally Advanced Oropharynx Cancer: a one-minute explainerNCT053887731 min

therapeutic conventional surgery trial for Oropharynx Cancer (NCT05388773). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with newly diagnosed, p16-positive oropharyngeal cancer without distant metastases, suitable for transoral surgery. Previous radiation above the collarbones excludes participation.

The idea: researchers test whether less treatment after surgery can retain cancer control. Low-risk patients receive observation. Intermediate-risk patients receive thirty gray of radiation over fifteen treatments. High-risk patients receive fifty gray over twenty-five treatments with weekly cisplatin; carboplatin substitutes when cisplatin cannot be used. Pathology determines the group.

This phase 2 study plans 150 patients. Heath Skinner leads at UPMC Hillman, Pittsburgh, the sole recruiting US site.

Public record; not medical advice.

Already in a trial?

It turns into a project to manage: visits, scans, labs, side effects and paperwork. Triangle keeps it organized in one place for you or for whoever's helping.

Organize my trial

7-day free trial, then $9 a month. Cancel anytime.