TriangleChemotherapy (NCT04643366)
Chemotherapy trial for Rectal Cancer (NCT04643366). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with resectable rectal adenocarcinoma that is T3–T4 or node-positive, without distant spread.
The idea: chemotherapy and radiation treat the cancer before surgery. Four cycles of fluorouracil, leucovorin, and oxaliplatin precede five radiation sessions with continuous fluorouracil, followed by four more chemotherapy cycles. Fluorouracil disrupts DNA production and RNA processing. Patients with a complete clinical response may choose close monitoring instead of surgery. Researchers measure three-year disease-free survival.
This phase 2 study plans 64 patients. Khalid Matin leads at VCU Massey, Richmond; three US sites recruit.
Public record; not medical advice.
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