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Biospecimen Collection (NCT07582172)

Total Marrow and Lymphoid Irradiation in Combination With Fludarabine and Melphalan as Conditioning for Allogeneic Peripheral Blood Stem Cell Hematopoietic Cell Transplant in Older Patients With Refractory and Relapsed Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome: a one-minute explainerNCT075821721 min

Biospecimen Collection trial for Acute Myeloid Leukemia With Complex Karyotype (NCT07582172). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for patients with qualifying active acute myeloid leukemia or high-blast myelodysplastic syndrome, including chronic myelomonocytic leukemia. Patients are generally 50 or older; ages 18–49 qualify if unsuitable for myeloablative conditioning. A matched stem-cell donor is required.

The idea: target marrow and lymphoid tissues with radiation, plus fludarabine and melphalan to attack cancer before donor-cell transplantation. Eight twice-daily fractions deliver sixteen gray. Patients receive palifermin, tacrolimus and sirolimus. Researchers assess leukemia-free survival and complications.

This phase 2 study plans 35 patients. Monzr Al Malki leads City of Hope’s recruiting Duarte site.

Public record; not medical advice.

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