TriangleBiospecimen Collection (NCT05691465)
Biospecimen Collection trial for Metastatic Prostate Adenocarcinoma With Neuroendocrine Differentiation (NCT05691465). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adult men with progressing metastatic prostate cancer meeting neuroendocrine criteria. A positive gallium-68 DOTATATE scan is required before treatment; chemotherapy is optional.
The idea: lutetium-177 DOTATATE binds somatostatin receptors and delivers radiation to receptor-bearing cells. Patients receive up to four infusions, six weeks apart. Researchers measure tumor response at six months and study radiation exposure and kidney effects. Testosterone suppression continues unless there was prior bilateral orchiectomy or the tumor is purely neuroendocrine.
This phase 2 study plans 35 patients. NCI sponsors ten recruiting US sites; John Floberg leads.
Public record; not medical advice.
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