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Biospecimen Collection (NCT03866382)

Testing the Effectiveness of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) With One Anti-cancer Targeted Drug (Cabozantinib) for Rare Genitourinary Tumors: a one-minute explainerNCT038663821 min

Biospecimen Collection trial for Bladder Adenocarcinoma (NCT03866382). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with specified rare genitourinary cancers that have spread. Eligibility depends on tumor type, prior therapy and whether disease is confined to bones. No prior cabozantinib is allowed.

The idea: combine daily oral cabozantinib, which blocks growth signals, with intravenous nivolumab and ipilimumab, which aim to support immune attack. Ipilimumab stops after four cycles; cabozantinib and nivolumab continue. Researchers measure tumor response and safety, with treatment lasting up to two years.

This phase 2 study plans 314 patients. NCI sponsors it; 222 US locations list recruitment.

Public record; not medical advice.

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