TriangleBiospecimen Collection (NCT07195734)
Biospecimen Collection trial for Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 (NCT07195734). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with locally recurrent or persistent head-and-neck squamous cancer after radiation, PD-L1 CPS at least 1, and no distant spread, who can have salvage surgery.
The idea: compare surgery with two preoperative carboplatin/paclitaxel cycles, with or without cemiplimab. Chemotherapy interferes with cancer-cell growth; cemiplimab supports immune attack. High-risk patients also receive postoperative radiation and cisplatin.
This phase 2 study plans 180 patients. Nabil Saba leads the NCI-sponsored trial, with 114 recruiting US sites. Prior systemic treatment for recurrent or metastatic disease is excluded.
Public record; not medical advice.
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