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Biopsy Procedure (NCT07281417)

Testing the Addition of Cemiplimab (REGN2810) to Chemotherapy Treatment Given Prior to Surgery in Patients With Sinonasal Squamous Cell Carcinoma: a one-minute explainerNCT072814171 min

Biopsy Procedure trial for Sinonasal Squamous Cell Carcinoma (NCT07281417). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with selected resectable, locally advanced sinonasal squamous-cell cancer without distant spread. HPV status must be documented. T3 tumors must meet additional surgical criteria.

The idea: compare carboplatin and paclitaxel with or without cemiplimab before definitive treatment. Cemiplimab blocks PD-1 to support immune attack. After two cycles, responding patients receive chemoradiation; stable or worsening disease leads to surgery followed by additional treatment. Researchers compare time before progression or death. Both groups receive chemotherapy.

This phase 2 study plans 108 patients. Siddharth Sheth leads eighteen recruiting US sites.

Public record; not medical advice.

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