TriangleNirogacestat (NCT05949099)
Nirogacestat trial for Desmoid Tumor (NCT05949099). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with a growing or symptomatic desmoid tumor. 50 to under 75 percent of its volume must be freezable in one session. Prior gamma-secretase or anti-Notch treatment is excluded.
The idea: nirogacestat blocks gamma-secretase, reducing Notch growth signals. Participants take 150 milligrams orally twice daily for three 28-day cycles, then have one tumor-freezing procedure. Treatment continues afterward, for up to 26 cycles. Researchers measure year-long tumor response or stability.
This phase 2 study plans 28 patients. Stanford’s Nam Bui leads it in Palo Alto, the single recruiting US site.
Public record; not medical advice.
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