Ultrahypofractionated Radiation (NCT07076485)

Name: Ultrahypofractionated Radiation trial for Breast Cancer (NCT07076485)
Uploaded: 2026-10-31T19:59:01.582Z
Duration: 1 min 11 s
Description: Ultrahypofractionated Radiation trial for Breast Cancer (NCT07076485). Who can join, how the treatment is intended to work, treatment groups and recruiting sites for NCT07076485.

Shortening Adjuvant Photon and Proton Irradiation (SAPPHIRe-II): A 4 Cohort, Randomized, Phase II Multi-center Trial Evaluating Shorter Schedules of Adjuvant Regional Nodal Irradiation Among Women and Men With Node-positive and High-risk Node-negative Invasive Breast Cancer: a one-minute explainerNCT070764851 min

Ultrahypofractionated Radiation trial for Breast Cancer (NCT07076485). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults needing regional lymph-node radiation after breast-cancer surgery with clear margins. The lower-risk mastectomy group requires age 40 or older.

The idea: patients enter groups based on surgery and recurrence risk. Lower-risk groups compare shorter radiation schedules. Higher-risk groups compare extra radiation given during the main course with extra radiation given afterward. Researchers assess side effects, cancer control, and patient experience.

This phase 2 study plans 768 patients. Benjamin Smith leads at MD Anderson in Houston; five US sites are recruiting.

Public record; not medical advice.

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