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Induction Chemotherapy (modified… (NCT06906887)

PULSO Trial: Pulsed Low-Dose-Rate (PLDR) Radiation Chemoradiation (CRT) vs. Standard CRT for Esophageal Cancer: a one-minute explainerNCT069068871 min

Induction Chemotherapy (modified FLOT or modified FOLFOX-6) trial for Esophageal Cancer (NCT06906887). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with stage II–IVB esophageal adenocarcinoma receiving induction chemotherapy before definitive chemoradiation. Stage IVB disease must have limited spread; more than five metastases exclude participation. Recurrent cancer is excluded.

The idea: patients are randomized to standard radiation or the same dose in small pulses separated by pauses, with chemotherapy. Researchers test whether pulsing reduces esophageal inflammation, pain-medication needs, and eating difficulties. Surgery is optional.

This phase 2 study plans 50 patients. Lindsay Puckett leads at Froedtert and the Medical College of Wisconsin, Milwaukee, the only recruiting US site.

Public record; not medical advice.

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