Carboplatin (NCT04682158)

Name: Carboplatin trial for Esophageal Adenocarcinoma (NCT04682158)
Uploaded: 2026-10-31T06:23:33.995Z
Duration: 1 min 18 s
Description: Carboplatin trial for Esophageal Adenocarcinoma (NCT04682158). Who can join, how the treatment is intended to work, treatment groups and recruiting sites for NCT04682158.

Propranolol With Chemotherapy or Chemoradiation for Esophageal Adenocarcinoma: a one-minute explainerNCT046821581 min

Carboplatin trial for Esophageal Adenocarcinoma (NCT04682158). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with esophageal adenocarcinoma receiving chemotherapy, chemotherapy plus immunotherapy, or chemoradiation before surgery or as definitive treatment. Patients must be suitable for beta-blocker use.

The idea: test adding propranolol, which blocks beta-adrenergic receptors, to standard treatment. The study includes treatment with and without propranolol and a group already taking beta-blockers. Propranolol is taken twice daily; feeding-tube delivery can be allowed.

This phase 2 study plans 106 patients. Anurag Singh leads at Roswell Park in Buffalo, the sole recruiting US site. Researchers assess safety, disease progression and surgical tumor response.

Public record; not medical advice.

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