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Surgical resection (NCT05546827)

Preoperative Radiotherapy and Immunotherapy for Sinonasal and Anorectal Mucosal Melanoma: a one-minute explainerNCT055468271 min

Surgical resection trial for Sinonasal Melanoma (NCT05546827). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with melanoma of the nasal passages, sinuses or anorectal canal, without distant spread. Combination checkpoint immunotherapy must be planned; prior radiation to that area is excluded.

The idea: immune treatment releases brakes on immune attack, then radiation treats the tumor before possible surgery. The pathway depends on tumor location, response and whether surgery can preserve structures. Some patients instead have a biopsy or continue other treatment. Researchers examine tissue response.

This phase 2 study plans 40 patients. MD Anderson leads it in Houston, the only recruiting US site.

Public record; not medical advice.

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