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Isatuximab (NCT05344833)

Post-Autologous Transplant Maintenance With Isatuximab and Lenalidomide in Minimal Residual Disease Positive Multiple Myeloma: a one-minute explainerNCT053448331 min

Isatuximab trial for Multiple Myeloma (NCT05344833). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for patients older than 18 with multiple myeloma and detectable residual disease after autologous transplantation, following at most two prior treatment lines.

The idea: intravenous isatuximab targets CD38 on myeloma cells, alongside oral lenalidomide. Maintenance starts before day 180 after transplant; marrow tests track residual disease. Isatuximab dosing becomes less frequent. Researchers assess complete responses with undetectable residual disease at one year. Patients resistant to anti-CD38 drugs or lenalidomide are excluded.

This phase 2 study plans 50 patients. University of Illinois Chicago sponsors it; two US sites are recruiting.

Public record; not medical advice.

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