High Rare Dose Rectal Brachytherapy… (NCT07292298)

Name: High Rare Dose Rectal Brachytherapy Boost trial for Rectal Adenocarcinoma (NCT07292298)
Uploaded: 2026-10-31T19:59:25.508Z
Duration: 1 min 15 s
Description: High Rare Dose Rectal Brachytherapy Boost trial for Rectal Adenocarcinoma (NCT07292298). Who can join, how the treatment is intended to work, treatment groups and recruiting sites for NCT07292298.

Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates: a one-minute explainerNCT072922981 min

High Rare Dose Rectal Brachytherapy Boost trial for Rectal Adenocarcinoma (NCT07292298). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for people aged 18–100 with mismatch-repair-proficient, nonmetastatic rectal adenocarcinoma remaining after chemotherapy and radiation. Residual tumors must meet strict size and location limits.

The idea: a rectal applicator delivers focused internal radiation in three weekly treatments totaling 21 gray. MRI and endoscopy guide planning. Researchers test whether this extra radiation can remove the need for major surgery. Complete responders enter surveillance; avoiding surgery is not assured.

This phase 2 study plans 44 patients. David Binder leads at the University of Colorado in Aurora, the sole recruiting US site.

Public record; not medical advice.

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