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Biospecimen Collection (NCT07121595)

Personalized Neck Radiation Therapy Directed by Sentinel Lymph Node Biopsy for the Treatment of Oral Cavity Squamous Cell Carcinoma, PRECEDENT Trial: a one-minute explainerNCT071215951 min

Biospecimen Collection trial for Oral Cavity Squamous Cell Carcinoma (NCT07121595). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for people over eighteen with oral-cavity squamous-cell cancer confined to one side, stage T1–T4aN0–N2bM0, without opposite-side neck disease. Surgery and sentinel-node evaluation must be planned.

The idea: a tracer and sentinel-node biopsy map where tumor drainage goes. Researchers use this information to personalize neck radiation and test whether selected patients can avoid radiation to the opposite side. The study measures opposite-side neck control at one year.

This phase 2 study plans 50 patients. Jennifer Shah leads at the University of Michigan in Ann Arbor, the sole recruiting US site.

Public record; not medical advice.

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