TriangleBiospecimen Collection (NCT07539454)
Biospecimen Collection trial for AIDS-Related Kaposi Sarcoma (NCT07539454). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with skin Kaposi sarcoma, newly diagnosed or resistant to or intolerant of previous treatment. Patients needing immediate cytotoxic chemotherapy are excluded. HIV-positive patients need controlled infection on antiretroviral treatment.
The idea: oral nirogacestat blocks gamma secretase and Notch signaling, aiming to limit tumor-cell growth. It is taken twice daily for up to twelve 28-day cycles. Skin lesions must support biopsies and response measurements.
This phase 2 study plans 28 patients. The AIDS Malignancy Consortium sponsors it. Siteman Cancer Center in St. Louis is the sole recruiting US site.
Public record; not medical advice.
Already in a trial?
It turns into a project to manage: visits, scans, labs, side effects and paperwork. Triangle keeps it organized in one place for you or for whoever's helping.
Organize my trial7-day free trial, then $9 a month. Cancel anytime.