Carboplatin (NCT05952453)

Name: Carboplatin trial for Ovarian Cancer (NCT05952453)
Uploaded: 2026-10-31T22:40:25.397Z
Duration: 1 min 22 s
Description: Carboplatin trial for Ovarian Cancer (NCT05952453). Who can join, how the treatment is intended to work, treatment groups and recruiting sites for NCT05952453.

Newly Diagnosed Stage III/IV Ovarian Cancer, Neoadjuvant Carbo/Taxol/Pembro, Maintenance Olaparib/Pembro: a one-minute explainerNCT059524531 min

Carboplatin trial for Ovarian Cancer (NCT05952453). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adult women with newly diagnosed stage III–IV epithelial ovarian, fallopian-tube, or peritoneal cancer, suitable for chemotherapy before planned debulking surgery.

The idea: initial carboplatin, with optional paclitaxel, precedes three carboplatin/paclitaxel/pembrolizumab cycles before surgery and three afterward. Maintenance combines olaparib, which blocks DNA repair, with pembrolizumab, which releases a PD1 immune brake. Bevacizumab is optional under specified conditions. Fresh tissue is required before treatment and at surgery. Researchers measure progression-free survival.

This phase 2 study plans 20 patients. Teresa Boitano leads at UAB, Birmingham, the sole recruiting US site.

Public record; not medical advice.

Read the full brief →

Already in a trial?

It turns into a project to manage: visits, scans, labs, side effects and paperwork. Triangle keeps it organized in one place for you or for whoever's helping.

Organize my trial

7-day free trial, then $9 a month. Cancel anytime.