TriangleBiospecimen Collection (NCT06863402)
Biospecimen Collection trial for Richter Syndrome (NCT06863402). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults whose CLL or SLL has transformed into diffuse large B-cell lymphoma. They must be unsuitable for initial anthracycline-based chemoimmunotherapy or have progression after prior transformation treatment. Previous checkpoint therapy is excluded.
The idea: combine daily nemtabrutinib tablets with pembrolizumab infusions every three weeks. Nemtabrutinib blocks BTK growth signaling; pembrolizumab releases the PD-1 immune brake. Treatment can continue for two years. Researchers measure responses, side effects and quality of life.
This phase 2 study plans 32 patients. Matthew Cortese leads Roswell Park's recruiting Buffalo site.
Public record; not medical advice.
Already in a trial?
It turns into a project to manage: visits, scans, labs, side effects and paperwork. Triangle keeps it organized in one place for you or for whoever's helping.
Organize my trial7-day free trial, then $9 a month. Cancel anytime.