TriangleAnti-Thymocyte Globulin (NCT01624805)
Anti-Thymocyte Globulin trial for Aplastic Anemia (NCT01624805). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults needing treatment for low-risk, intermediate-one-risk, or hypocellular myelodysplastic syndrome, or aplastic anemia when donor transplant is unsuitable. Prior treatment is allowed.
The idea: horse anti-thymocyte globulin, methylprednisolone, and cyclosporine suppress immune cells thought to contribute to low blood counts. Filgrastim and/or pegfilgrastim support white-cell growth. Initial infusions last four days; steroids taper, and oral cyclosporine continues for up to six months. Researchers measure blood-count responses, safety, and survival.
This phase 2 study plans 140 patients. Tapan Kadia leads at MD Anderson, Houston, the sole recruiting US site.
Public record; not medical advice.
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