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Biopsy Procedure (NCT07583810)

Marginal zone lymphoma: nemtabrutinib and rituximab: a one-minute explainerNCT075838101 min

Biopsy Procedure trial for Conjunctival Mucosa-Associated Lymphoid Tissue Lymphoma (NCT07583810). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with marginal zone lymphoma that needs treatment, whether previously treated or untreated. Transformed lymphoma is excluded. Prior non-covalent BTK inhibitors are excluded.

The idea: combine daily oral nemtabrutinib with rituximab infusions. Nemtabrutinib blocks BTK, an enzyme involved in cancer-cell growth. Rituximab binds CD20 on B cells, aiming to help the immune system kill cancer cells. Researchers will check safety and how often lymphoma disappears on assessment.

This phase 2 study plans 35 patients. Geoffrey Shouse leads at City of Hope in Duarte, California, the only recruiting US site.

Public record; not medical advice.

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