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Gallium Ga 68-DOTATATE (NCT04082520)

Lutathera for the Treatment of Inoperable, Progressive Meningioma After External Beam Radiation Therapy: a one-minute explainerNCT040825201 min

Gallium Ga 68-DOTATATE trial for Grade 1 Meningioma (NCT04082520). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with progressive meningioma after radiation, without a safe further radiation option or curative surgery option. A DOTATATE PET scan must show sufficient somatostatin-receptor uptake. Grade 1 and grade 2–3 tumors are assessed separately.

The idea: Lutathera binds somatostatin receptors and delivers radioactive lutetium to those cells. Patients receive up to four infusions, eight weeks apart, with scans, blood tests and questionnaires. Researchers assess six-month disease control and toxicity. Optic-nerve-sheath and extracranial meningiomas are excluded.

This phase 2 study plans 42 patients. Kenneth Merrell leads Mayo’s recruiting Rochester site.

Public record; not medical advice.

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