TriangleL19IL2/L19TNF (NCT07227870)
L19IL2/L19TNF trial for Locally Advanced Basal Cell Carcinoma (NCT07227870). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with locally advanced basal-cell skin cancer that progressed on, or could not tolerate, both hedgehog inhibitors and anti-PD1 treatment. An injectable skin or subcutaneous lesion is required; visceral metastases are excluded.
The idea: L19IL2/L19TNF targets tumor-associated fibronectin to deliver immune-stimulating proteins. Injections into tumors occur weekly for four weeks. A second course is optional for partial response or stable disease. Biopsies help confirm response; researchers also assess safety.
This phase 2 study plans 92 patients. Philogen sponsors; three US sites recruit, in Tampa, Atlanta, and Houston.
Public record; not medical advice.
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