TriangleHigh dose testosterone (NCT05011383)
High dose testosterone trial for Metastatic Prostate Cancer (NCT05011383). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adult men with metastatic castration-resistant prostate cancer, an inactivating ATM, CDK12 or CHEK2 mutation, and progression after an androgen-receptor signaling inhibitor. Symptoms must be absent or minimal.
The idea: test whether DNA-repair defects predict response to high-dose testosterone. Monthly injections under the skin accompany ongoing androgen deprivation. Researchers measure sustained PSA reductions, progression and side effects; benefit is uncertain.
This phase 2 study plans 51 patients. VA’s Robert Montgomery leads it; 16 US sites are recruiting, including Seattle.
Public record; not medical advice.
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