TrianglePersonalis NeXT Personal (NCT07459673)
Personalis NeXT Personal trial for Breast Cancer (NCT07459673). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with breast cancer metastatic at diagnosis, HER2 IHC 3+, and no previous systemic breast-cancer treatment. Patients must be potential surgical candidates; brain metastases are excluded.
The idea: blood tumor-DNA tests and scans guide changes in sequential HER2 treatment. Trastuzumab deruxtecan targets HER2 and delivers a DNA-damaging drug; pertuzumab also targets HER2. Local treatment is part of the strategy. Researchers measure sustained imaging and molecular complete responses.
This phase 2 study plans 60 patients. Pedram Razavi leads at Memorial Sloan Kettering in New York; seven US sites are recruiting.
Public record; not medical advice.
Already in a trial?
It turns into a project to manage: visits, scans, labs, side effects and paperwork. Triangle keeps it organized in one place for you or for whoever's helping.
Organize my trial7-day free trial, then $9 a month. Cancel anytime.