TriangleTotal-Body Irradiation (NCT03970096)
Total-Body Irradiation trial for Acute Leukemia (NCT03970096). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for people aged 1–60 with eligible acute or related blood cancers in remission, or previously treated myelodysplastic syndrome. An HLA-matched stem-cell donor is required; some radiation-based regimens limit age to 50.
The idea: compare removing naive T cells from donor grafts against cyclophosphamide after transplant to reduce graft-versus-host disease. Conditioning and other immune-suppressing medicines differ by group. Researchers measure survival without relapse or serious graft-versus-host disease.
This phase 2 study plans 120 patients. Marie Bleakley leads at Fred Hutchinson in Seattle, with three recruiting US sites. Two arms are discontinued.
Public record; not medical advice.
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