TriangleArchive Sample Retrieval (NCT07708961)
Archive Sample Retrieval trial for Glioblastoma, IDH-Wildtype (NCT07708961). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with IDH-wild-type glioblastoma carrying a pathogenic EGFR mutation, after standard radiation with temozolomide and before starting post-radiation temozolomide. True disease progression excludes entry.
The idea: randomly assign temozolomide alone or with oral WSD0922-FU. Temozolomide damages DNA; WSD0922-FU blocks EGFR growth signals and can reach the brain. Researchers test whether the addition delays progression or death. Some patients may receive WSD0922-FU before surgery after recurrence.
This phase 2 study plans 60 patients. Sani Kizilbash leads at Mayo Clinic in Rochester, with three recruiting US sites.
Public record; not medical advice.
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