Systemic Therapy (NCT06649058)

Name: Systemic Therapy trial for Brain Metastases (NCT06649058)
Uploaded: 2026-10-31T06:37:05.538Z
Duration: 1 min 20 s
Description: Systemic Therapy trial for Brain Metastases (NCT06649058). Who can join, how the treatment is intended to work, treatment groups and recruiting sites for NCT06649058.

EXCLAIM: Exploring Combined Local and Systemic Approaches In Brain Metastasis: a Multi-cohort Randomized Phase II Study Evaluating Initial Response to Systemic Therapy and Subsequent Integration of Stereotactic Radiosurgery in Patients With Low-risk Brain Metastases and Central Nervous System-active: a one-minute explainerNCT066490581 min

Systemic Therapy trial for Brain Metastases (NCT06649058). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for selected adults with small brain metastases. A specialist team must agree that brain-active systemic treatment can start safely before local treatment. Small-cell lung cancer, leukemia, lymphoma and certain targeted-treatment situations are excluded.

The idea: use systemic treatment first. After partial response or stable disease, randomize focused brain radiation versus observation. Complete responses are observed. If brain disease progresses, compare radiation to growing lesions alone versus all lesions without complete response.

This phase 2 study plans 316 patients. Thomas Beckham leads MD Anderson's single recruiting US site in Houston.

Public record; not medical advice.

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