TriangleCyclophosphamide (NCT07428993)
Cyclophosphamide trial for Pediatric Osteosarcoma (NCT07428993). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for patients aged 21 or younger with newly diagnosed, high-risk metastatic osteosarcoma who complete standard chemotherapy without progression.
The idea: patients’ T cells are collected and prepared as B7-H3-targeting CAR T cells. After standard chemotherapy and tumor surgery, eligible patients receive lymphodepleting chemotherapy followed by the cell infusion. When lung surgery is needed, its timing depends on the regimen cleared in safety testing. Researchers measure event-free survival.
This phase 2 study plans 41 patients. Julie Park leads at St. Jude in Memphis, the sole recruiting US site.
Public record; not medical advice.
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