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Androgen Receptor Pathway Inhibitor (NCT07466498)

Estrogen to Improve Quality of Life for Men With Newly Diagnosed or Recurrent Metastatic Hormone Sensitive Prostate Cancer, EQUIP Trial: a one-minute explainerNCT074664981 min

Androgen Receptor Pathway Inhibitor trial for Castration-Sensitive Prostate Adenocarcinoma (NCT07466498). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adult men with new or recurrent metastatic, hormone-sensitive prostate cancer. Prior chemotherapy for hormone-sensitive disease, LHRH therapy and next-generation androgen-receptor treatment are excluded.

The idea: compare estrogen skin patches with usual LHRH hormone therapy. Both groups add an androgen-receptor signaling inhibitor after four weeks to block androgen effects on cancer. Researchers assess hot flashes and quality of life. Severe hot flashes can permit switching to patches after 12 weeks.

This phase 2 study plans 60 patients. Michael Schweizer leads at Fred Hutchinson in Seattle, the sole recruiting US site.

Public record; not medical advice.

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