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FACT-B (NCT02476786)

Endocrine Treatment Alone for Elderly Patients With Estrogen Receptor Positive Operable Breast Cancer and Low Recurrence Score: a one-minute explainerNCT024767861 min

FACT-B trial for Breast Cancer (NCT02476786). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for women aged seventy or older with operable ER-positive, HER2-negative breast cancer, stages T1–T2, N0–N1, M0. Ki67 must be ≤30%, or the mitotic index low to intermediate. Prior surgery for this cancer is excluded.

The idea: physician-selected endocrine therapy reduces estrogen signaling to test whether it can control cancer without immediate surgery. Tumors are assessed every three to six months. Patients may choose standard treatment anytime; progression prompts its recommendation.

This phase 2 study plans 50 patients. Rebecca Aft leads at Washington University, St. Louis, the sole recruiting US site.

Public record; not medical advice.

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