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Stereotactic Body Radiation Therapy… (NCT07770100)

Concurrent Immunotherapy and Systemic Therapy With Stereotactic Body Radiation Therapy (SBRT) for Stage IV Cancers (COINSSS IV): a one-minute explainerNCT077701001 min

Stereotactic Body Radiation Therapy (SBRT) trial for Head and Neck Cancer (NCT07770100). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults aged 18–99 with advanced head-and-neck, non-small-cell lung, cervical, esophageal, gastric or gastroesophageal cancer. Six or more metastases must permit radiation, plus another measurable lesion.

The idea: combine focused radiation to six to ten metastases with checkpoint drugs that release immune brakes. Patients must be on their first immunotherapy-based treatment line; drug-specific biomarker rules apply. One measurable lesion remains untreated with radiation. Researchers assess six-month progression-free survival and safety.

This phase 2 study plans 35 patients. Mark Bernard sponsors the recruiting University of Kentucky Markey site in Lexington.

Public record; not medical advice.

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