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Staged Stereotactic Radiosurgery… (NCT07227610)

Brain Metastases in Greater Size - Hypofractionated Options Trial (BIGSHOT): a one-minute explainerNCT072276101 min

Staged Stereotactic Radiosurgery (SSRS) trial for Brain Metastases (NCT07227610). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with one or two brain metastases measuring two to five centimeters, who are stable enough to avoid immediate surgery and have no prior radiation to that area.

The idea: compare focused radiation in two sessions about a month apart with three or five sessions over a shorter period. Random assignment selects the schedule. Researchers track tumor control, further treatment and radiation-related tissue damage.

This phase 2 study plans 54 patients. Charlotte Rivers leads it at the Medical University of South Carolina in Charleston, the single recruiting US site.

Public record; not medical advice.

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