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Biospecimen Collection (NCT06014827)

Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase Inhibitor in Oligoprogressive Oncogenic Positive Non-Small Cell Lung Carcinoma: a one-minute explainerNCT060148271 min

Biospecimen Collection trial for Lung Non-Small Cell Carcinoma (NCT06014827). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with metastatic non-small-cell lung cancer carrying EGFR exon-19 deletion or L858R, progressing at one to five sites outside the brain after over six months of stability on first-line osimertinib alone.

The idea: continue osimertinib, which blocks EGFR growth signals, while precisely targeting progressing tumors with five radiation treatments. At least one lung or bone lesion must qualify for biologically guided radiation. Researchers monitor disease control and tolerability.

This phase 2 study plans 32 patients. Arya Amini leads at City of Hope, Duarte, the sole recruiting US location.

Public record; not medical advice.

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