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Biospecimen Collection (NCT06525766)

Adaptive Therapy With Capecitabine for Treatment of Metastatic ER Positive, HER2 Negative Breast Cancer: a one-minute explainerNCT065257661 min

Biospecimen Collection trial for Anatomic Stage IV Breast Cancer AJCC v8 (NCT06525766). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with metastatic ER-positive, HER2-negative breast cancer starting capecitabine or within its first two cycles. Prior chemotherapy or antibody-drug conjugates for metastatic disease are excluded.

The idea: capecitabine becomes fluorouracil, which attacks cancer cells. Patients take tablets twice daily for fourteen days in each three-week cycle. After response or stable disease, scans and biomarkers guide dosing. Researchers test whether patients can complete adaptive cycles while tracking cancer progression and quality of life.

This phase 2 study plans 35 patients. Mayo Clinic leads in Scottsdale, the sole recruiting US site.

Public record; not medical advice.

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