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Acoustic Cluster Therapy (NCT06850623)

Acoustic Cluster Therapy (ACT) With Chemotherapy for the Treatment of Locally Advanced Pancreatic Cancer: a one-minute explainerNCT068506231 min

Acoustic Cluster Therapy trial for Locally Advanced Pancreatic Adenocarcinoma (NCT06850623). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for adults with untreated, locally advanced or borderline-resectable pancreatic cancer who are not suitable for curative surgery and can receive modified FOLFIRINOX chemotherapy. Previous pancreatic cancer treatment excludes entry; bypass procedures and bile-duct stents are allowed.

The idea: combine PS101 with ultrasound directed at the tumor and chemotherapy. Acoustic Cluster Therapy is given on day one of up to eight two-week chemotherapy cycles. CT scans every eight weeks assess tumor response; visits assess well-being and toxicity.

This phase 2 study plans 25 patients. EXACT Therapeutics sponsors seven recruiting US sites.

Public record; not medical advice.

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