TriangleBiospecimen Collection (NCT05504291)
Biospecimen Collection trial for Bilateral Retinoblastoma (NCT05504291). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for children younger than 18 with newly diagnosed retinoblastoma confined to the eye, including a Group D eye with tumor seeds in its vitreous fluid.
The idea: melphalan damages cancer-cell DNA. It may be injected inside the eye from cycle three, alongside intravenous carboplatin, vincristine, and etoposide. Examinations under anesthesia determine injection eligibility. Those not eligible receive systemic chemotherapy alone. Researchers assess feasibility, safety, and tumor control; injections are not automatic.
This phase 2 study plans 26 patients. Rachana Shah leads for Children's Oncology Group; 16 US sites are recruiting.
Public record; not medical advice.
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