Biospecimen Collection (NCT04684368)

Name: Biospecimen Collection trial for Central Nervous System Nongerminomatous Germ Cell Tumor (NCT04684368)
Uploaded: 2026-10-31T21:04:39.079Z
Duration: 1 min 19 s
Description: Biospecimen Collection trial for Central Nervous System Nongerminomatous Germ Cell Tumor (NCT04684368). Who can join, how the treatment is intended to work, treatment groups and recruiting sites for NCT04684368.

A Study of a New Way to Treat Children and Young Adults With a Brain Tumor Called NGGCT: a one-minute explainerNCT046843681 min

Biospecimen Collection trial for Central Nervous System Nongerminomatous Germ Cell Tumor (NCT04684368). This is a short film with English narration. The transcript is on this page, and the written brief is separate.

What the film says

Read the transcript

This trial is for patients aged three to twenty-nine with newly diagnosed, localized nongerminomatous germ-cell tumors in the pineal or suprasellar brain region. Previous tumor treatment beyond surgery or steroids excludes participation.

The idea: start six chemotherapy cycles, choose treatment using scans, tumor markers and sometimes second-look surgery. Radiation covers the brain's ventricles and spinal canal for qualifying responders. Others receive intensive chemotherapy, stem-cell rescue and broader radiation. These treatments aim to kill tumor cells; researchers track relapse.

This phase 2 study plans 160 patients. Children's Oncology Group lists 142 recruiting US sites.

Public record; not medical advice.

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