TriangleBiospecimen Collection (NCT06661915)
Biospecimen Collection trial for Accelerated Phase Myeloproliferative Neoplasm (NCT06661915). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults weighing at least 50 kilograms with Philadelphia-negative myeloproliferative cancers or MDS/MPN overlap and at least 10% blasts. Prior DNA-methyltransferase inhibitors and IDH1-mutated blast-phase MPN exclude participation.
The idea: compare oral decitabine/cedazuridine with or without iadademstat after dose escalation. Iadademstat blocks LSD1, aiming to alter gene activity controlling cancer-cell growth. Cedazuridine slows decitabine breakdown. Researchers compare leukemia response within four cycles and track survival and transplant rates.
This phase 2 study plans 78 patients. NCI sponsors it; 32 US locations list recruitment.
Public record; not medical advice.
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