TriangleCD105/Yb-1/SOX2/CDH3/MDM2-polyepitope… (NCT07078604)
CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine trial for Anatomic Stage IV Breast Cancer AJCC v8 (NCT07078604). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with PD-L1-negative metastatic triple-negative breast cancer, at most one prior metastatic treatment line, and no prior metastatic immunotherapy. Biopsy-accessible disease is required.
The idea: STEMVAC is designed to train immune cells against five proteins associated with breast cancer stem cells. Patients continue standard chemotherapy and receive vaccine with sargramostim into the skin: three priming doses three to four weeks apart, followed by boosters. Researchers assess immune responses and safety, with biopsies.
This phase 2 study plans 20 patients. Brie Chun leads in Seattle, the sole recruiting US site.
Public record; not medical advice.
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