TriangleEarly-Stage Resectable Non-Small Cell Lung CancerNCT06566443Papers
Honokiol
Honokiol in Early-Stage Resectable Non-Small Cell Lung Cancer
Dose level -1 100 mg po once daily Dose level 1 150 mg po once daily Dose level 2 200 mg po once daily
Valemetostat
Valemetostat in Combination With Atezolizumab in People With Lung Cancer
- RegistryNCT06807632
- PhasePhase 1
- StatusRecruiting
- ConditionExtensive-stage Small-cell Lung Cancer
- SponsorMemorial Sloan Kettering Cancer Center
The drug
What is being tested.
The study
How the trial runs.
This study will test whether valemetostat in combination with atezolizumab is a safe treatment that causes few or mild side effects in people with extensive-stage small cell lung cancer (SCLC). The researchers will test different doses of valemetostat to find the highest dose that causes few or mild side effects in participants.
After the dose is found, researchers will test it in a new group of participants to learn more about the safety of the study treatment and see if it is an effective treatment for extensive-stage SCLC.
Eligibility
Who the study is looking for.
- Signed informed consent form (ICF)
- Ability to comply with the study protocol as per the investigator's judgment
- Age ≥ 18 years at the time of signing the ICF
- Life expectancy ≥ 12 weeks
- ECOG performance status 0 or 1
- Pathologically confirmed diagnosis of newly diagnosed extensive-stage small cell lung cancer. Patients with a diagnosis of combined small cell lung cancer with other histologies may be considered for inclusion if the predominant histology is SCLC and only after discussion with the study PI.
Inclusion criteria as written on the registry, trimmed. The full list, with exclusions, is on the live record.
For you, or someone you love
Whether or not this trial is the one, bring AI into your corner.
A complex diagnosis brings new questions every week, in a trial and out of one. Triangle keeps your whole medical file together, reads it with you in plain language, and helps you and your family decide what to ask next.
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Every record in one place
Requested from your hospitals and clinics through the national networks. Add scans, pathology and anything on paper.
Read in plain words
Reports explained as they come in, with lab values you can follow before treatment, during a trial and after.
Ready for every appointment
Ask about your own file, and walk in with questions for your oncologist or the trial team.
Your people, in the loop
Share one profile with the family helping you, and with your doctors.
Members also get a deeper analysis of their records and any sequencing data, including clinical trials that may fit, reviewed by a licensed physician before they receive it.
How these trials work: what Phase 1 actually is · common questions Not clinical evidence.
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