TriangleSABRE (NCT07172958)
SABRE trial for Relapsed/Refractory Embryonal Tumors (NCT07172958). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for children and young adults, ages 1 to 23, with relapsed or refractory rhabdomyosarcoma, Ewing sarcoma, neuroblastoma or Wilms tumor.
The idea: give two kinds of engineered T cells together. One carries a B7-H3 receptor, and the other targets a tumor protein called PRAME. The cells are made from each patient's own blood, collected by apheresis. Patients first receive lymphodepleting chemotherapy.
This phase 1 study plans 18 participants and tests safety. At Children's National in Washington, D.C., Holly Meany and Amy Hont lead it.
Public record; not medical advice.
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How these trials work: what Phase 1 actually is · common questions Not clinical evidence.