TrianglePapaverine (NCT05136846)
Papaverine trial for Locally Advanced Lung Non-Small Cell Carcinoma (NCT05136846). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for stage 2 or 3 non small cell lung cancer that cannot be removed by surgery, in adults.
The idea: add papaverine to radiation. Papaverine targets mitochondrial metabolism, which is how cells make energy, and may work best given together with chemoradiation. It is given by vein or by injection under the skin, at rising doses.
The first question is the highest dose patients can tolerate. The trial plans 28 patients. At Ohio State University in Columbus, Jeremy Brownstein leads it.
Public record; not medical advice.
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How these trials work: what Phase 1 actually is · common questions Not clinical evidence.