TriangleLeflunomide (NCT04997993)
Leflunomide trial for PTEN-Altered Advanced Solid Tumors and HER2-Negative Breast Cancer (NCT04997993). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
What the film says
Read the transcript
This trial is for adults with advanced solid tumors that have a PTEN alteration, or with HER2 negative breast cancer.
The idea: test leflunomide, a daily pill already used for other conditions. The first part finds the highest dose that can be given safely. A later part looks for early signs of benefit.
This phase 1 study plans 23 patients. At the Icahn School of Medicine at Mount Sinai in New York, Deborah Doroshow leads it.
Public record; not medical advice.
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