TriangleRIOT 4B (NCT07443020)
RIOT 4B trial for Malignant Pleural Effusion (NCT07443020). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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When cancer spreads to the lining of the lung, fluid builds up and breathing becomes work. Doctors drain it, often through a catheter that stays in place, and the fluid is thrown away.
The idea: that fluid is full of immune cells that have already found the tumor. Use them.
At West Penn Hospital in Pittsburgh, the fluid goes to a lab in the same building. Its T cells are pulled out and multiplied over days, not weeks. After chemotherapy makes room, the cells return through the same chest catheter, straight to the tumor, with low doses of interleukin-2 given locally to keep them working.
RIOT 4B, with Patrick Wagner, is the first test in people. Safety first. Public record; not medical advice.
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