TriangleIvonescimab + Radiosurgery (NCT07535463)
Ivonescimab + Radiosurgery trial for Non-Small Cell Lung Cancer With Brain Metastases (NCT07535463). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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This trial is for adults with non-small cell lung cancer that has spread to the brain.
The idea: combine ivonescimab, an antibody given by vein, with standard chemotherapy and stereotactic radiosurgery, a focused high dose of radiation to the brain tumors given in three sessions. The dose of ivonescimab is raised in steps to find the best dose with few or mild side effects. That dose is then tested in a new group.
This phase 1 and 2 study plans 53 patients. At Memorial Sloan Kettering Cancer Center in New York, Luke Pike leads it.
Public record; not medical advice.
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