TriangleMRI-Guided Adaptive RT (NCT04808323)
MRI-Guided Adaptive RT trial for Locally Advanced Rectal Adenocarcinoma (NCT04808323). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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This trial is for adults with locally advanced rectal cancer, stage one to three, with the goal of preserving the rectum.
The idea: give higher doses of radiation focused on the tumor, using MRI guided adaptive radiation therapy, where the plan is adjusted in real time on MRI. Capecitabine chemotherapy is given during radiation, then FOLFOX chemotherapy after. Three groups test rising doses.
The study looks at side effects and the maximum tolerated dose.
This phase 1 study plans 22 patients. At the Medical College of Wisconsin in Milwaukee, William Hall and Carrie Peterson lead it.
Public record; not medical advice.
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