TriangleDecipHER (NCT05504707)
DecipHER trial for Triple Negative Breast Cancer (NCT05504707). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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This trial is for early-stage breast cancer that is triple negative or has low estrogen receptor levels.
The idea: train immune cells outside the body, then inject them into the tumor. Dendritic cells, which present targets to other immune cells, are primed with two proteins, HER2 and HER3. Participants receive eight ultrasound-guided injections into the tumor, twice a week, alongside standard chemotherapy given before surgery.
The study raises the dose in three steps to find the highest dose with acceptable side effects. At Moffitt Cancer Center in Tampa, Ricardo Costa leads it.
Public record; not medical advice.
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