TriangleAxatilimab (NCT06523556)
Axatilimab trial for Advanced Myeloproliferative Neoplasms, MDS/MPN and High-Risk CMML (NCT06523556). This is a short film with English narration. The transcript is on this page, and the written brief is separate.
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This trial is for adults with advanced myeloproliferative neoplasms, overlap syndromes with myelodysplastic syndrome, or high risk chronic myelomonocytic leukemia.
The idea: give axatilimab, an antibody given by vein that blocks a protein on certain white blood cells that may help the cancer grow. The first part tests axatilimab alone. The second part adds azacitidine, a standard chemotherapy.
The study looks for the best dose and how well it works.
This phase 1 and 2 study plans 49 patients. At Ohio State University Comprehensive Cancer Center in Columbus, Uma Borate leads it.
Public record; not medical advice.
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