Treatment of Progressive or Recurrent Retinoblastoma

External-beam radiation therapy or plaque radiotherapy.

Cryotherapy.

Thermotherapy.

Systemic chemotherapy or ophthalmic artery infusion chemotherapy.

Intravitreal chemotherapy.

Surgery (enucleation).

A clinical trial of targeted therapy with an oncolytic virus that targets the RB1 gene and is injected into the tumor.

A clinical trial that checks a sample of the patient's tumor for certain gene changes. The type of targeted therapy that will be given to the patient depends on the type of gene change.

Systemic chemotherapy and external-beam radiation therapy for retinoblastoma that comes back after surgery to remove the eye.

Systemic chemotherapy followed by high-dose chemotherapy with stem cell rescue and external-beam radiation therapy.

A clinical trial that checks a sample of the patient's tumor for certain gene changes. The type of targeted therapy that will be given to the patient depends on the type of gene change.