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Ultrasound-guided percutaneous cryosurgery

Source: Prostate Cancer Treatment (PDQ®)–Health Professional Version, National Cancer Institute.

Source updated: May 14, 2025 · Captured 2026-09-09.

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Context: Treatment of Stage II Prostate Cancer / Treatment Options for Stage II Prostate Cancer

Cryosurgery is a surgical technique that involves destruction of prostate cancer cells by intermittent freezing of the prostate with cryoprobes followed by thawing.[46][Level of evidence C1]; [47,48][Level of evidence C3] Cryosurgery is less well established than standard prostatectomy, and long-term outcomes are not as well established as with prostatectomy or radiation therapy. Serious toxic effects include:

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Bladder outlet injury.

Urinary incontinence.

Sexual impotence.

Rectal injury.

The frequency of other side effects and the probability of cancer control at 5 years of follow-up have varied among reporting centers, and series are small compared with surgery and radiation therapy.[47,48]

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Preserved source evidence · Not medical advice